منابع مشابه
MeSHDD: Literature-based drug-drug similarity for drug repositioning
Objective Drug repositioning is a promising methodology for reducing the cost and duration of the drug discovery pipeline. We sought to develop a computational repositioning method leveraging annotations in the literature, such as Medical Subject Heading (MeSH) terms. Methods We developed software to determine significantly co-occurring drug-MeSH term pairs and a method to estimate pair-wise ...
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The rapid adoption of electronic health records (EHR) provides a comprehensive source for exploratory and predictive analytic to support clinical decision-making. In this paper, we investigate how to utilize EHR to tailor treatments to individual patients based on their likelihood to respond to a therapy. We construct a heterogeneous graph which includes two domains (patients and drugs) and enc...
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$L$-fuzzy rough sets are extensions of the classical rough sets by relaxing theequivalence relations to $L$-relations. The topological structures induced by$L$-fuzzy rough sets have opened up the way for applications of topological factsand methods in granular computing. In this paper, we firstly prove thateach arbitrary $L$-relation can generate an Alexandrov $L$-topology.Based on this fact, w...
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Understanding drugs and their modes of action is a fundamental challenge in systems medicine. Key to addressing this challenge is the elucidation of drug targets, an important step in the search for new drugs or novel targets for existing drugs. Incorporating multiple biological information sources is of essence for improving the accuracy of drug target prediction. In this article, we introduce...
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INTRODUCTION Confinement of biomolecules in structured nanoporous materials offers several desirable features ranging from chemical and thermal stability, to resistance to degradation from the external environment. A new generation of mesoporous materials presents exciting new possibilities for the formulation and controlled release of biological agents. Such materials address niche application...
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ژورنال
عنوان ژورنال: Anaesthesia
سال: 1996
ISSN: 0003-2409
DOI: 10.1111/j.1365-2044.1996.tb07814.x